(Updated 3/24/2013) Many brackets have long been in the trash, but little-known schools continued to knock off some powerhouses of the game on the second day of the Round of 32 in the NCAA Men’s Basketball Tournament.

So far this year, there have been 12 games in which a lower-seeded team beat a higher-seeded team, and three of those upsets played out on March 23.

The first shocker of the day was No. 10 seed Stanford edging out No. 2 seed Kansas, 60-57, in the South region. Stanford held Kansas freshman guard Andrew Wiggins to just four points and stole the Sweet 16 away from one of the favorites to reach the Final Four.

Another Final Four favorite, No. 1 seed Wichita State, was also knocked off in a 78-76 loss to No. 8 seed Kentucky in the Midwest region. It was the first loss for Wichita State, who ended its season with a 35-1 record.

No. 3 seed Creighton also disappointed, being routed by No. 6 seed Baylor, 85-55, in the West region. Creighton senior Doug McDermott is the consensus Player of the Year after averaging 27 points and seven rebounds per game this season, but the star forward was held to just 15 points and two rebounds in the loss.

Other scores from March 23:

East Region

No. 1 Virginia defeated No. 8 Memphis, 78-60
No. 3 Iowa State defeated No. 6 North Carolina, 85-83

Midwest Region

No. 11 Tennessee defeated No. 13 Mercer, 83-63

South Region

No. 4 UCLA defeated No. 12 SF Austin, 77-60