By LAURAN NEERGAARD,
Associated Press News
Pfizer’s COVID-19 vaccine gave children five and older strong protection against hospitalization and death, even during the omicron surge that hit youth especially hard, U.S. health officials reported.
New data from the Centers for Disease Control and Prevention come the day after a study of New York children suggested the vaccine may not be as effective for 5- to 11-year-olds as in older kids — especially at blocking milder infections. That data raised the question of whether kid-sized doses given to those under 12-years might be too low.
But the CDC said data from multiple other states suggests the issue isn’t the child’s age or dose size — it’s Omicron. Vaccination generally is less effective against the severely contagious Omicron variant than earlier versions of the coronavirus and vaccinations for 5- to 11-year-olds began just weeks before omicron began circulating.
“As a parent of a very young child, I think I would do everything to keep them out of the emergency department in the middle of the night,” said CDC epidemiologist Ruth Link-Gelles. “What we see from the data we have is that the vaccine continues to provide good protection against more severe outcomes.”
Pediatricians say the back-and-forth results may seem confusing but parents need to understand that vaccines are still the best way to prevent serious illnesses.
“If you’re vaccinated, you may get a mild infection and we’re just going to have to learn to live with that,” said Dr. Paul Offit of the Children’s Hospital of Philadelphia.
He said the New York study was too small to draw conclusions and also can’t account for variables such as infections going uncounted in kids tested at home instead of at a clinic. He said children admitted to his hospital with severe COVID-19 are usually unvaccinated “and it’s hard to watch.”
The CDC reported March 8 that between April and early January there were nine deaths related to COVID-19 among vaccinated children ages 5 to 17 compared to 121 deaths among unvaccinated children at that age.
Also, the CDC examined pediatric hospitalizations in 10 states from last April to the end of January. The vaccine proved 74 percent effective against hospitalization in 5- to 11-year-olds. Only two vaccinated children were hospitalized compared to 59 unvaccinated children.
In comparison, the vaccine was 92 percent to 94 percent effective against hospitalization in 12- to 15-year-olds and 16- to 17-year-olds. Most of the hospitalizations in the adolescents occurred when the earlier Delta variant was dominant, while most of the hospitalizations of those younger than 12 occurred during the Omicron wave, which started in early December.
The study on March 8 also found that during the time when Omicron was predominant, the vaccine was 51% effective in preventing emergency room or urgent care visits by 5- to 11-year-olds. That was fairly similar to the 45 percent effectiveness for 12- to 15-year-olds who’d gotten their second dose months earlier.
What about less serious outcomes?
A report released March 7 from researchers with the New York State Department of Health analyzed health records week-by-week from early December through the end of January. Vaccine effectiveness against any COVID-19 infection dropped from 68 percent to just 12 percent by the height of Omicron’s wave. But among kids 12 and older, that effectiveness dropped to just 51 percent.
Remarkably, the data suggested 12-year-olds appeared to have the most protection of any age, prompting the researchers to ask if maybe the dose should be reexamined.
The Pfizer shots are the only vaccine available to U.S. children, and those ages 5 to 11 receive one-third of the dose given to everyone 12 and older. Also, those within that age group is urged to get a booster dose to strengthen protection against Omicron.
The CDC’s latest study didn’t track infections the same way, but Link-Gelles said surveillance data from 29 other states doesn’t suggest a difference between the younger and older kids.
Unvaccinated 5- to 11-year-olds were 1.3 times more likely to get COVID-19 in January — at the height of the Omicron surge — than vaccinated children, according to new CDC data. For 12- to 17-year-olds, the unvaccinated were 1.5 times more likely to get COVID-19 than their vaccinated peers that month.
It’s disappointing that protection against infection isn’t higher, and it may take more research to tell if younger children might fare better with a different dose, said Dr. Richard Besser, a pediatrician and president and CEO of the Robert Wood Johnson Foundation, who wasn’t involved with the new studies.
Pfizer currently is testing a booster dose for 5- to 11-year-olds.
But meanwhile, “We do know if these vaccines are safe, what we do know is that they reduce the risk of hospitalization,” Besser said.
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